DAY 1 :

PHYSICIAN CME DAY (Friday, Nov. 30th)

Location: BMO Conference Centre – Toronto Western Hospital
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7:00am

8:00am

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8:05am

8:45am


9:05am


9:25am

10:00am

–––––––

10:15am


10:35am



11:00am


11:20am

12:00pm


 

–––––––
 

1:00pm

 

1:20pm


 

1:40pm


 

2:00pm

 

2:20pm

2:50pm

–––––––
 

3:10pm

 

3:30pm

 

3:50pm

 

4:10pm
 

4:30pm

5:00pm

Registration and Breakfast Buffet

Opening Remarks

Genetics of HTAD

Precision medicine: History and Evolution of Genetic Aortic Disorders

Head to toe: System-based diagnosis of HTAD
• Overview of clinical diagnosis
• Spectrum of associated systemic features and findings on history & physical exam

Genetic diagnosis of HTAD
• Who to test, what to test for
• Family history – role of family screening
• Interpretation of testing results

Panel discussion with cases from the audience

~ BREAK

Surveillance and Counselling

Imaging the aorta and vascular tree
• Measurement techniques + standardization
• Z-scores and indexed areas
• What to image, which modality, and how often

Implications of an HTAD diagnosis: Aortic risk and beyond
• Natural history vs. clinical history
• Lifestyle – exercise – employment
• Family planning – family screening
• Education + patient advocacy

Pregnancy and HTAD
• Surgical thresholds for patients contemplating pregnancy
• Imaging and medical treatment during pregnancy
• Role of IVF and pre-implantation diagnosis

Panel discussion with cases from the audience

~ LUNCH:
A mechanistic approach to heritable thoracic aortic disorders: from gene to mouse to patient
 

Risk Assessment and Medical Management

Therapeutic targets for HTAD
• Rationale behind beta blockers, ARBs
• Novel targets – where are we headed

Contemporary ‘real world’ medical management
• Risk factor control
• Initiation / titration of BB/ARB
• Other: IE prophylaxis – statins – doxy

Surgical thresholds in 2018
• Diagnosis-specific recommendations
• What are thresholds based on?
• Contrast Canadian – US – European guidelines

Predictors of aortic risk beyond size
• Tortuosity and Stiffness – biomechanics
• Inflammation, other biomarkers

Panel discussion with cases from the audience

~ BREAK

Surgical Management of HTAD

Surgery on the proximal aorta
• Root repair techniques
• Elective vs emergency operations

Surgery on the distal aorta
• Hybrid arch repair
• Chronic distal dissections

Stent grafts in HTAD
• Current role
• Advances in design / bioengineering

Management of acute type B dissection in HTAD
• Complicated and uncomplicated acute type B

Panel discussion with cases from the audience

Adjourn

 

Dr. Barry Rubin, Director PMCC

–––––––––––––––

Dr. Dianna Milewicz
Houston

Dr. Gabrielle Horne
Halifax

 

Dr. Julien Marcadier
Calgary

 

 

Outside Meeting Room

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Dr. Francois-Pierre Mongeon
Montreal
 


Dr. Reed Pyeritz
Philadelphia


 

Dr. Jasmine Grewal
Vancouver

 

 


Keynote speaker
Dr. Hal Dietz

Baltimore

–––––––––––––––
 

Dr. Pascal Bernatchez
Vancouver
 

Dr. Tim Bradley
Saskatchewan

 

Dr. Munir Boodhwani
Ottawa

 

Dr. Shaine Morris
Houston
 

 

Outside Meeting Room

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Dr. Ismail El-Hamamsy
Montreal
 

Dr. Maral Ouzounian
Toronto
 

Dr. Tom Forbes
Toronto
 

Dr. Sherene Shalhub
Seattle

DAY 2 :

PATIENT & FAMILY EDUCATION DAY (Saturday, Dec. 1st)

Location: BMO Conference Centre - Toronto Western Hospital
-------------------------------------------–––--------------------------------––

7:00am

8:00am

–––––––
 

8:10am

8:40am

9:10am

9:40am

10:10am

10:30am


 

11:15am


 

12:00pm

–––––––

1:00pm

1:20pm

1:40pm

2:00pm

2:20pm

2:30pm


3:15pm


4:00pm

Registration and Breakfast Buffet

Opening Remarks

Cardiovascular Manifestations

Diagnosis and medical treatment of HTAD

Genetic testing for HTAD

Aortic surgery for HTAD

Panel Q&A

~ NETWORK BREAK

Simultaneous workshops – Part 1
Genetics – Dr. Milewicz, Dr. Richer, Dr. Marcadier; 
Cardiology – Dr. Bradley, Dr. Keir; 
Cardiac surgery – Dr. Ouzounian, Dr. El-Hamamsy

Simultaneous workshops – Part 2
Genetics – Dr. Pyeritz, Dr. Dietz, Dr. Laberge; 
Cardiology – Dr. Alvarez, Dr. Horne; 
Cardiac surgery – Dr. Ouzounian, Dr. El-Hamamsy

~ LUNCH

Systemic Challenges

Ophthalmology

Orthopedics

Pain management

Panel Q&A

~ NETWORK BREAK

Simultaneous workshops – Part 3
Ophthalmology – Dr. Maumenee; 
Orthopedics – Dr. Ouellet; 
Pain – Dr. Mittal, Ms. McGillis;

Simultaneous workshops – Part 4
Ophthalmology – Dr. Maumenee; 
Orthopedics – Dr. Ouellet; 
Pain – Dr. Mittal, Ms. McGillis;

Conclude

Dr. Barry Rubin, Director PMCC

–––––––––––––––
 

Dr. Michelle Keir – Calgary

Dr. Julie Richer – Ottawa

Dr. Maral Ouzounian – Toronto

All faculty

Outside Meeting Room




 




 

Outside Meeting Room

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Dr. Irene Maumenee – New York

Dr. Jean Ouellet – Montreal

Dr. Nimish Mittal – Toronto

All faculty

Outside Meeting Room